Bacterial plasmids are ubiquitous ‘minichromosomes’ that have major importance in clinical microbiology, as agents of pathogenicity and as carriers of antibiotic resistance, and in molecular genetics, through their role as vectors in gene manipulation. Plasmids carry a wide range of dispensable, transiently useful and often bizarre functions.1 Naturally occurring plasmids, in addition to modifying the host cell phenotype, carry genes involved in the control of their own vegetative replication, plasmid copy number2 and stable inheritance. They may also carry determinants for (...) the conjugal transfer of DNA between bacteria.3 Whereas low‐copy‐number plasmids must be partitioned by some active process during cell division, the evidence suggests that multicopy plasmids are distributed randomly between daughter cells. Two independent determinants are necessary for the stable inheritance of multicopy plasmids, and both of these appear to act by maximizing the number of independent plasmid molecules. (shrink)

[This is an edited version of a keynote talk at the conference on Neural Information Processing Systems (NeurIPS) on November 28, 2022, with some minor additions and subtractions.] -/- There has recently been widespread discussion of whether large language models might be sentient or conscious. Should we take this idea seriously? I will break down the strongest reasons for and against. Given mainstream assumptions in the science of consciousness, there are significant obstacles to consciousness in current models: for example, their (...) lack of recurrent processing, a global workspace, and unified agency. At the same time, it is quite possible that these obstacles will be overcome in the next decade or so. I conclude that while it is somewhat unlikely that current large language models are conscious, we should take seriously the possibility that successors to large language models may be conscious in the not-too-distant future. (shrink)

This book provides a conceptual basis for recognizing the classroom as an ecology of linguistic and cultural patterns that should be taken into account as part of the teacher's professional decision making. It argues that the orchestration of classroom behaviour cannot be separated from the mental ecology of metaphor and thought patterns that reflect the student's primary culture. Chapters discuss the metaphorical nature of language and thought, primary socilization, nonverbal communication, framing and social control, the classroom as an ecology of (...) power, culturally responsive supervision, and educating teachers for the 21st century - all from a cultural and linguistic point of view. (shrink)

This brief overview argues that the evidence of the images themselves, as well as their contexts, suggests that some Franco‐Cantabrian Upper Paleolithic cave art was, at least in part, intimately associated with various shamanic practices. Universal features of altered states of consciousness and the deep caves combined to create notions of a subterranean spirit‐world that became, amongst other ritual areas, the location of vision quests.

What are the philosophical views of professional philosophers, and how do these views change over time? The 2020 PhilPapers Survey surveyed around 2000 philosophers on 100 philosophical questions. The results provide a snapshot of the state of some central debates in philosophy, reveal correlations and demographic effects involving philosophers' views, and reveal some changes in philosophers' views over the last decade.

Personal observations and survey data are used to examine the future of the village in a restructured food and agricultural sector in the former Soviet Union. Specific comparisons are made between the subjective quality of life of residents in two villages in the former Soviet Union (one in southern Russia and one in eastern Ukraine) and two villages in northwest Missouri. Residents of the Russian and Ukrainian villages have substantially lower assessments of specific domains of their lives than do American (...) villagers. Respondents in the Russian and Ukrainian sample express an interest in some aspects of privatization of services and consumer goods but, by and large, exhibit little interest in replacing the collective farms with household-level private farming. Historical factors, different incentive structures, and the possibilities for different institutional arrangements are discussed. (shrink)

Microscale techniques have been applied to biological assays for nearly two decades, but haven't been widely integrated as common tools in biological laboratories. The significant differences between several physical phenomena at the microscale versus the macroscale have been exploited to provide a variety of new types of assays (such as gradient production or spatial cell patterning). However, the use of these devices by biologists seems to be limited by issues regarding biological validation, ease of use, and the limited available readouts (...) for assays done using microtechnology. Critical validation work has been done recently that highlights the current challenges for microfluidic methods and suggest ways in which future devices might be improved to better integrate with biological assays. With more validation and improved designs, microscale techniques hold immense promise as a platform to study aspects of cell biology that are not possible using current macroscale techniques. BioEssays 30:811–821, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This chapter describes three relatively specific forms such as destructive uploading, gradual uploading, and nondestructive uploading. Neuroscience is gradually discovering various neural correlates of consciousness, but this research program largely takes the existence of consciousness for granted. It presents an argument for the pessimistic view and an argument for the optimistic view, both of which run parallel to related arguments that can be given concerning teletransportation. Cryonic technology offers the possibility of preserving our brains in a low‐temperature state shortly after (...) death, until such time as the technology is available to reactivate the brain or perhaps to upload the information in it. Reconstructive uploading from brain scans is closely akin to ordinary (nongradual) uploading from brain scans, with the main difference being the time delay, and perhaps the continued existence in the meantime of the original person. (shrink)

In this short introduction, David J. Gunkel examines the shifting world of artificial intelligence, mapping it onto everyday twenty-first century life and probing the consequences of this ever-growing industry and movement. The book investigates the significance and consequences of the robot invasion in an effort to map the increasingly complicated social terrain of the twenty-first century. Whether we recognize it as such or not, we are in the midst of a robot invasion. What matters most in the face of (...) this machine incursion is not resistance, but how we decide to make sense of and respond to the social opportunities and challenges that autonomous machines make available. How to Survive a Robot Invasion is a fascinating and accessible volume for students and researchers of new media, philosophy of technology, and their many related fields. It aims both to assist readers' efforts to understand a changing world and to provide readers with the critical insight necessary for grappling with our science fiction-like future. (shrink)

Taking a social identity approach to health behaviors, this research examines whether experimentally “activating” the human identity is an effective public-health strategy to curb the spread of COVID-19. Three goals of the research include examining: whether the human identity can be situationally activated using an experimental manipulation, whether activating the human identity causally increases behavioral intentions to protect the self and others from COVID-19, and whether activating the human identity causally increases behaviors that help protect vulnerable communities from COVID-19. Across (...) two preregistered experiments, results suggest the manipulation of identification with humanity had a significant but small effect on participants’ psychological bond with all humanity, but not their concern for all humanity. However, the manipulation had no causal effect on health-related behavioral intentions or helping behaviors that reduce the spread of COVID-19. Limitations, future directions, and direct benefits of the research are discussed. (shrink)

Through a philosophical lens, this book explores the powerful educational capabilities of classic psychedelics.

This essay examines whether and to what extent the “other” in communicative interactions may be otherwise than another human subject and the moral opportunities and challenges this alteration would make available to us. Toward this end, the analysis proceeds in five steps or movements. The first reviews the way the discipline of communication has typically perceived and theorized the role and function of technology. The second and third parts investigate the critical challenges that emerging technology, such as artificial intelligence applications (...) and robots, poses to this standard instrumentalist way of thinking. The fourth part introduces an alternative called “relational ethics,” which effectively flips the script on the usual way of proceeding. And the fifth part presents and responds to one important and notable objection to this alternative. The goal in all of this is not to complicate things but to introduce and formulate a techno-ethics that is more agile in its response to the opportunities and challenges of the 21st century and beyond. (shrink)

The book is an extended study of the problem of consciousness. After setting up the problem, I argue that reductive explanation of consciousness is impossible , and that if one takes consciousness seriously, one has to go beyond a strict materialist framework. In the second half of the book, I move toward a positive theory of consciousness with fundamental laws linking the physical and the experiential in a systematic way. Finally, I use the ideas and arguments developed earlier to defend (...) a form of strong artificial intelligence and to analyze some problems in the foundations of quantum mechanics. (shrink)

Introduction -- Repression, ignorance, and undone science -- The epistemic dimension of the political opportunity structure -- The politics of meaning: from frames to design conflicts -- The organizational forms of counterpublic knowledge -- Institutional change, industrial transitions, and regime resistance politics -- Contemporary change: liberalization and epistemic modernization -- Conclusion.

We elaborate on Glowacki's claim that humans are more capable of establishing peace than other mammals. We present three aspects suggesting caution. First, the social capabilities of nonhuman primates should not be underestimated. Second, the effect of these capabilities on peace establishment is nonmonotonous. Third, defining peace by human-centered values introduces a fallacy.

Standing on the Shoulders of Darwin and Mendel: Early Views of Inheritance explores early theories about the mechanisms of inheritance. Beginning with Charles Darwin's now rejected Gemmule hypothesis, the book documents the reception of Gregor Mendel's work on peas and follows the work of early 20th century scholars. The research of Francis Galton, a cousin of Darwin, and the friction it caused between these two are a part of longer story of the development of genetics and an understanding of how (...) offspring inherit the characteristics of their parents. Bateson, Garrod, de Vries, Tschermak and others are all characters in a scientific story of discovery, acrimony, cooperation and revelation. (shrink)

We extend Ivancovsky et al.'s finding on the association between curiosity and creativity by proposing a sequential causal model assuming that (a) curiosity determines the motivation to seek information and that (b) creativity constitutes a capacity to act on that motivation. This framework assumes that both high levels of curiosity and creativity are necessary for information-seeking behavior.

Doctors’ strikes are legally permissible in the UK, with the situation differing in other countries. But are they morally permissible? Doug McConnell and Darren Mann have systematically attempted to dismiss the arguments for the moral impermissibility of doctors’ strikes and creatively attempted to provide further moral justification for them. Unfortunately for striking doctors, they fail to achieve this. Meanwhile, junior doctors’ strikes have continued in the UK through 2023 and have now extended into 2024. In this response, which focuses on (...) the UK situation and specifically junior doctors’ strikes in the National Health Service (NHS) in England, I will demonstrate a central problem with their arguments—namely that they underplay the harms caused by prolonged doctors’ strikes by ignoring the harms to patients with cancer. This weakens their conclusion that strikes are morally permissible in terms of the conditions and thresholds they set. I then provide a psychological critique of their justification for strikes in terms of the interests of the public. It follows that invoking the controversial concept of supererogatory action is ungrounded but also absurd when you consider time-critical cancer care. If those representing striking doctors wish to maintain a modicum of moral respectability, they should mitigate for patients with cancer and negotiate reasonably and with urgency. (shrink)

This paper is in three parts. In the first part, I consider Maritain’s definition of freedom. He differentiates between two types of freedom: freedom of choice, which he also calls freedom from necessity, and freedom of autonomy or terminal freedom, also called freedom from constraint. The second part considers the three types of political philosophy of freedom identified by Maritain. They may respectively be called liberal individualism, statesponsored collectivism, and communal and personalist philosophy. The third political philosophy, communal and personalist, (...) is advocated by Maritain. In the third part of this paper, I raise concerns about losses of freedom that have become more evident in the last few years during the COVID-19 pandemic, and I reflect upon how Maritain’s philosophy of freedom may apply in our contemporary situation. (shrink)

Does consciousness collapse the quantum wave function? This idea was taken seriously by John von Neumann and Eugene Wigner but is now widely dismissed. We develop the idea by combining a mathematical theory of consciousness (integrated information theory) with an account of quantum collapse dynamics (continuous spontaneous localization). Simple versions of the theory are falsified by the quantum Zeno effect, but more complex versions remain compatible with empirical evidence. In principle, versions of the theory can be tested by experiments with (...) quantum computers. The upshot is not that consciousness-collapse interpretations are clearly correct, but that there is a research program here worth exploring. (shrink)

There is a long tradition in philosophy of using a priori methods to draw conclusions about what is possible and what is necessary, and often in turn to draw conclusions about matters of substantive metaphysics. Arguments like this typically have three steps: first an epistemic claim , from there to a modal claim , and from there to a metaphysical claim.

Rethinking the powers of the imagination, Søren Kierkegaard both anticipates and challenges contemporary approaches to a descriptive philosophy of religion. In contrast to the reigning approaches to religion in his day, Kierkegaard reconceives philosophy as, first of all, descriptive of human, including specifically ethical and religious, existence. To this end, he develops conceptual tools, including a descriptive ontology of human existence, a “pluralist epistemology” exploring both cognitive and passional dimensions of religion, and a role for the poetic in philosophy, strikingly (...) expressed in his observer figures who “imaginatively construct” “thought projects” to explore human existence. While this new descriptive account anticipates subsequent approaches to the philosophy of religion, it could be interpreted as another “objectivist” endeavor, yet Kierkegaard attempts more in this descriptive philosophy. He imaginatively deploys conceptual and rhetorical strategies maieutically to both describe and elicit self-reflection aimed at transformation, thus expanding the imagination’s uses for his readers. Comparing Kierkegaard to Pierre Hadot’s recovery of ancient Greek philosophy as “a way of life” will show how Kierkegaard also engages the particularity of “the Christian principle”, with implications for how philosophy can both describe and elicit the pathos of other religious traditions as well. (shrink)

Is conceptual analysis required for reductive explanation? If there is no a priori entailment from microphysical truths to phenomenal truths, does reductive explanation of the phenomenal fail? We say yes . Ned Block and Robert Stalnaker say no.

Why is two-dimensional semantics important? One can think of it as the most recent act in a drama involving three of the central concepts of philosophy: meaning, reason, and modality. First, Kant linked reason and modality, by suggesting that what is necessary is knowable a priori, and vice versa. Second, Frege linked reason and meaning, by proposing an aspect of meaning (sense) that is constitutively tied to cognitive signi?cance. Third, Carnap linked meaning and modality, by proposing an aspect of meaning (...) (intension) that is constitutively tied to possibility and necessity. (shrink)

This chapter analyzes aspects of the relationship between consciousness and intentionality. It focuses on the phenomenal character and the intentional content of perceptual states, canvassing various possible relations among them. It argues that there is a good case for a sort of representationalism, although this may not take the form that its advocates often suggest. By mapping out some of the landscape, the chapter tries to open up territory for different and promising forms of representationalism to be explored in the (...) future. In particular, it argues for a nonreductive, narrow, and Fregean variety of representationalism, which contrasts strongly with more widely explored varieties. It concludes with some words about the fundamental relationship between consciousness and intentionality. (shrink)